8IJR

The cryo-EM structure of human sphingomyelin synthase-related protein in complex with diacylglycerol/phosphoethanolamine

8IJR の概要

• エントリーDOI: 10.2210/pdb8ijr/pdb
• EMDBエントリー: 35493
• 分子名称: Sphingomyelin synthase-related protein 1, (2S)-1-(hexadecanoyloxy)-3-hydroxypropan-2-yl (11Z)-octadec-11-enoate, PHOSPHORIC ACID MONO-(2-AMINO-ETHYL) ESTER (3 entities in total)
• 機能のキーワード: synthase, sphingomyelin, cpe, membrane protein, lipid metabolism
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 294092.66

構造登録者

Hu, K.,Zhang, Q.,Chen, Y.,Yao, D.,Zhou, L.,Cao, Y. (登録日: 2023-02-28, 公開日: 2024-02-28, 最終更新日: 2024-07-03)

• 主引用文献: Hu, K.,Zhang, Q.,Chen, Y.,Yang, J.,Xia, Y.,Rao, B.,Li, S.,Shen, Y.,Cao, M.,Lu, H.,Qin, A.,Jiang, X.C.,Yao, D.,Zhao, J.,Zhou, L.,Cao, Y.; Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis.; Nat.Struct.Mol.Biol., 31:884-895, 2024; PubMed: 38388831; DOI: 10.1038/s41594-024-01237-2

実験手法

ELECTRON MICROSCOPY (3.29 Å)