8IJQ

The cryo-EM structure of human sphingomyelin synthase-related protein in complex with ceramide

Summary for 8IJQ

• Entry DOI: 10.2210/pdb8ijq/pdb
• EMDB information: 35492
• Descriptor: Sphingomyelin synthase-related protein 1, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE (2 entities in total)
• Functional Keywords: synthase, sphingomyelin, cpe, membrane protein, lipid metabolism
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 189566.58

Authors

Hu, K.,Zhang, Q.,Chen, Y.,Yao, D.,Zhou, L.,Cao, Y. (deposition date: 2023-02-27, release date: 2024-02-28, Last modification date: 2024-07-03)

• Primary citation: Hu, K.,Zhang, Q.,Chen, Y.,Yang, J.,Xia, Y.,Rao, B.,Li, S.,Shen, Y.,Cao, M.,Lu, H.,Qin, A.,Jiang, X.C.,Yao, D.,Zhao, J.,Zhou, L.,Cao, Y.; Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis.; Nat.Struct.Mol.Biol., 31:884-895, 2024; PubMed: 38388831; DOI: 10.1038/s41594-024-01237-2

Experimental method

ELECTRON MICROSCOPY (3.45 Å)