8IJC
NMR solution structure of the 1:1 complex of a platinum(II) ligand L1-transpt covalently bound to a G-quadruplex MYT1L
Summary for 8IJC
Entry DOI | 10.2210/pdb8ijc/pdb |
Descriptor | G-quadruplex DNA MYT1L, Pt(NH3)2(2-(pyridin-4-ylmethyl)benzo-[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone) (2 entities in total) |
Functional Keywords | g-quadruplex dna, quadruplex-duplex hybrid, platinum complex, dna |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 9803.36 |
Authors | Liu, L.-Y.,Mao, Z.-W. (deposition date: 2023-02-27, release date: 2023-06-28, Last modification date: 2024-05-15) |
Primary citation | Liu, L.Y.,Ma, T.Z.,Zeng, Y.L.,Liu, W.,Zhang, H.,Mao, Z.W. Organic-Platinum Hybrids for Covalent Binding of G-Quadruplexes: Structural Basis and Application to Cancer Immunotherapy. Angew.Chem.Int.Ed.Engl., 62:e202305645-e202305645, 2023 Cited by PubMed: 37464955DOI: 10.1002/anie.202305645 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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