8II2

Crystal structure of V30M-TTR in complex with BBM

8II2 の概要

• エントリーDOI: 10.2210/pdb8ii2/pdb
• 分子名称: Transthyretin, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: thyroxine, amyloidosis, inhibitor, transport protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35573.41

構造登録者

Yokoyama, T. (登録日: 2023-02-24, 公開日: 2023-06-28)

• 主引用文献: Mizuguchi, M.,Yokoyama, T.,Okada, T.,Nakagawa, Y.,Fujii, K.,Nabeshima, Y.,Toyooka, N.; Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis.; Bioorg.Med.Chem., 90:117370-117370, 2023; PubMed: 37311373; DOI: 10.1016/j.bmc.2023.117370

実験手法

X-RAY DIFFRACTION (1.798 Å)