8I7V

Cryo-EM structure of Acipimox bound human hydroxy-carboxylic acid receptor 2 in complex with Gi heterotrimer

8I7V の概要

• エントリーDOI: 10.2210/pdb8i7v/pdb
• EMDBエントリー: 35234
• 分子名称: Human hydroxycarboxylic acid receptor 2,Hydroxycarboxylic acid receptor 2,Hydroxycarboxylic acid receptor 2, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• 機能のキーワード: gpcr, g-protein, membrane protein, acipimox, signaling
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 168534.96

構造登録者

Park, J.H.,Ishimoto, N.,Park, S.Y. (登録日: 2023-02-02, 公開日: 2024-02-07)

• 主引用文献: Park, J.H.,Kawakami, K.,Ishimoto, N.,Ikuta, T.,Ohki, M.,Ekimoto, T.,Ikeguchi, M.,Lee, D.S.,Lee, Y.H.,Tame, J.R.H.,Inoue, A.,Park, S.Y.; Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2.; Nat Commun, 14:7150-7150, 2023; PubMed: 37932263; DOI: 10.1038/s41467-023-42764-8

実験手法

ELECTRON MICROSCOPY (2.77 Å)