8I7L

Crystal structure of indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with a novel inhibitor

Summary for 8I7L

• Entry DOI: 10.2210/pdb8i7l/pdb
• Descriptor: Indoleamine 2,3-dioxygenase 1, THIOSULFATE, 1-[3-[(4-chloranyl-2-fluoranyl-phenyl)carbamoylamino]-4-[cyclohexyl(2-methylpropyl)amino]phenyl]pyrrole-2-carboxylic acid, ... (4 entities in total)
• Functional Keywords: inhibitor, metal binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 91934.61

Authors

Li, K.,Liu, W.,Dong, X. (deposition date: 2023-02-01, release date: 2023-02-15, Last modification date: 2024-05-01)

• Primary citation: Liu, W.,Zou, Y.,Li, K.,Zhong, H.,Yu, L.,Ge, S.,Lai, Y.,Dong, X.,Xu, Q.,Guo, W.; Apo-Form Selective Inhibition of IDO for Tumor Immunotherapy.; J Immunol., 209:180-191, 2022; PubMed: 35725271; DOI: 10.4049/jimmunol.2100938

Experimental method

X-RAY DIFFRACTION (2.8 Å)