8I71

Hepatitis B virus core protein Y132A mutant in complex with Linvencorvir (RG7907), a Hepatitis B Virus (HBV) Core Protein Allosteric Modulator (CpAM)

8I71 の概要

• エントリーDOI: 10.2210/pdb8i71/pdb
• 分子名称: Capsid protein, CHLORIDE ION, ISOPROPYL ALCOHOL, ... (7 entities in total)
• 機能のキーワード: capsid assembly inhibitor, antiviral protein, viral protein
• 由来する生物種: Hepatitis B virus subtype adyw
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 109678.26

構造登録者

Zhou, Z.,Xu, Z.H. (登録日: 2023-01-30, 公開日: 2023-03-22, 最終更新日: 2023-04-05)

• 主引用文献: Zhang, W.,Guo, L.,Liu, H.,Wu, G.,Shi, H.,Zhou, M.,Zhang, Z.,Kou, B.,Hu, T.,Zhou, Z.,Xu, Z.,Zhou, X.,Zhou, Y.,Tian, X.,Yang, G.,Young, J.A.T.,Qiu, H.,Ottaviani, G.,Xie, J.,Mayweg, A.V.,Shen, H.C.,Zhu, W.; Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection.; J.Med.Chem., 66:4253-4270, 2023; PubMed: 36896968; DOI: 10.1021/acs.jmedchem.3c00173

実験手法

X-RAY DIFFRACTION (1.6 Å)