8I6B

Crystal structure of Mycobacterium tuberculosis Uracil-DNA glycosylase in complex with 5-Hydroxy-2,4(1H,3H)-pyrimidinedione, Form I

8I6B の概要

• エントリーDOI: 10.2210/pdb8i6b/pdb
• 分子名称: Uracil-DNA glycosylase, 5-oxidanyl-1~{H}-pyrimidine-2,4-dione, 1,2-ETHANEDIOL, ... (7 entities in total)
• 機能のキーワード: dna repair, base excision repair, inhibitor-complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26523.71

構造登録者

Raj, P.,Paul, A.,Gopal, B. (登録日: 2023-01-27, 公開日: 2023-07-12, 最終更新日: 2024-05-08)

• 主引用文献: Kesharwani, S.,Raj, P.,Paul, A.,Roy, K.,Bhanot, A.,Mehta, A.,Gopal, A.,Varshney, U.,Gopal, B.,Sundriyal, S.; Crystal structures of non-uracil ring fragments in complex with Mycobacterium tuberculosis uracil DNA glycosylase (MtUng) as a starting point for novel inhibitor design: A case study with the barbituric acid fragment.; Eur.J.Med.Chem., 258:115604-115604, 2023; PubMed: 37399710; DOI: 10.1016/j.ejmech.2023.115604

実験手法

X-RAY DIFFRACTION (1.6 Å)