8I1J
Crystal structure of human MTH1(G2K/D120N mutant) in complex with 2-oxo-dATP at pH 9.7
Summary for 8I1J
Entry DOI | 10.2210/pdb8i1j/pdb |
Descriptor | 7,8-dihydro-8-oxoguanine triphosphatase, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate, SODIUM ION, ... (4 entities in total) |
Functional Keywords | nudix hydrolase, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 37191.53 |
Authors | Nakamura, T.,Yamagata, Y. (deposition date: 2023-01-13, release date: 2023-03-22, Last modification date: 2023-07-26) |
Primary citation | Nakamura, T.,Koga-Ogawa, Y.,Fujimiya, K.,Chirifu, M.,Goto, M.,Ikemizu, S.,Nakabeppu, Y.,Yamagata, Y. Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition. Febs Lett., 597:1770-1778, 2023 Cited by PubMed: 36914375DOI: 10.1002/1873-3468.14611 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.08 Å) |
Structure validation
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