8HY1
Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-(thiophen-2-ylmethyl)thiazole-4-carboxylic acid
Summary for 8HY1
Entry DOI | 10.2210/pdb8hy1/pdb |
Descriptor | Beta-lactamase class B VIM-2, ZINC ION, 2-azanyl-5-(thiophen-2-ylmethyl)-1,3-thiazole-4-carboxylic acid, ... (4 entities in total) |
Functional Keywords | beta-lactamase class b vim-2, hydrolase |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 2 |
Total formula weight | 50101.12 |
Authors | |
Primary citation | Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B. Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. J.Med.Chem., 66:13746-13767, 2023 Cited by PubMed: 37791640DOI: 10.1021/acs.jmedchem.3c01189 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.937 Å) |
Structure validation
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