8HXS

Small_spotted catshark CD8alpha

Summary for 8HXS

• Entry DOI: 10.2210/pdb8hxs/pdb
• Descriptor: T-cell surface glycoprotein CD8 alpha chain (2 entities in total)
• Functional Keywords: cartilaginous fishes, cd8alpha, cytokine
• Biological source: Scyliorhinus canicula (smaller spotted catshark)
• Total number of polymer chains: 1
• Total formula weight: 11322.79

Authors

Wang, J.,Zou, J. (deposition date: 2023-01-05, release date: 2023-02-22, Last modification date: 2024-11-13)

Primary citation

Jia, Z.,Feng, J.,Dooley, H.,Zou, J.,Wang, J.
The first crystal structure of CD8 alpha alpha from a cartilaginous fish.
Front Immunol, 14:1156219-1156219, 2023

PubMed Abstract: Cartilaginous fishes are the most evolutionary-distant vertebrates from mammals and possess an immunoglobulin (Ig)- and T cell-mediated adaptive immunity. CD8 is the hallmark receptor of cytotoxic T cells and is required for the formation of T cell receptor-major histocompatibility complex (TCR-MHC) class I complexes.

PubMed: 37122697
DOI: 10.3389/fimmu.2023.1156219

Experimental method

X-RAY DIFFRACTION (1.35 Å)