8HUL

X-ray structure of human PPAR delta ligand binding domain-lanifibranor co-crystals obtained by co-crystallization

8HUL の概要

• エントリーDOI: 10.2210/pdb8hul/pdb
• 分子名称: Peroxisome proliferator-activated receptor delta, 4-[1-(1,3-benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl]butanoic acid (2 entities in total)
• 機能のキーワード: nuclear receptor, protein-ligand complex, ppar, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63925.13

構造登録者

Kamata, S.,Honda, A.,Machida, Y.,Uchii, K.,Shiiyama, Y.,Masuda, R.,Oyama, T.,Ishii, I. (登録日: 2022-12-24, 公開日: 2023-08-09, 最終更新日: 2023-09-06)

• 主引用文献: Kamata, S.,Honda, A.,Ishikawa, R.,Akahane, M.,Fujita, A.,Kaneko, C.,Miyawaki, S.,Habu, Y.,Shiiyama, Y.,Uchii, K.,Machida, Y.,Oyama, T.,Ishii, I.; Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor.; Antioxidants, 12:-, 2023; PubMed: 37627519; DOI: 10.3390/antiox12081523

実験手法

X-RAY DIFFRACTION (2.461 Å)