8HPA

Monkeypox virus DNA replication holoenzyme F8, A22 and E4 complex in a DNA binding form

Summary for 8HPA

Entry DOI	10.2210/pdb8hpa/pdb
EMDB information	34684 34927 34929
Descriptor	DNA polymerase, DNA polymerase processivity factor component A20, E4R, ... (5 entities in total)
Functional Keywords	monkeypox virus, dna replication holoenzyme, dna replication machinery, f8, a22, e4, dna polymerase, b-family dna polymerase, uracil-dna glycosylase, mpxv, orthopoxvirus, poxviridae, f8-a22-e4 complex, dna processivity factor, viral protein
Biological source	Monkeypox virus More
Total number of polymer chains	5
Total formula weight	212198.52
Authors	Xu, Y.,Wu, Y.,Zhang, Y.,Fan, R.,Yang, Y.,Li, D.,Yang, B.,Zhang, Z.,Dong, C. (deposition date: 2022-12-12, release date: 2024-01-31, Last modification date: 2025-06-18)
Primary citation	Xu, Y.,Wu, Y.,Zhang, Y.,Fan, R.,Yang, Y.,Li, D.,Zhu, S.,Yang, B.,Zhang, Z.,Dong, C. Cryo-EM structures of human monkeypox viral replication complexes with and without DNA duplex. Cell Res., 33:479-482, 2023 Cited by PubMed: 36973539 DOI: 10.1038/s41422-023-00796-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.01 Å)

Structure validation