8HLM

Crystal structure of p53/BCL2 fusion complex (complex 2)

Summary for 8HLM

• Entry DOI: 10.2210/pdb8hlm/pdb
• Descriptor: Cellular tumor antigen p53, Apoptosis regulator Bcl-2, ZINC ION, ... (4 entities in total)
• Functional Keywords: apoptosis
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 41670.79

Authors

Guo, M.,Wang, H.,Wei, H.,Chen, Y. (deposition date: 2022-11-30, release date: 2023-07-26, Last modification date: 2024-05-29)

• Primary citation: Wei, H.,Wang, H.,Wang, G.,Qu, L.,Jiang, L.,Dai, S.,Chen, X.,Zhang, Y.,Chen, Z.,Li, Y.,Guo, M.,Chen, Y.; Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity.; Nat Commun, 14:4300-4300, 2023; PubMed: 37463921; DOI: 10.1038/s41467-023-40087-2

Experimental method

X-RAY DIFFRACTION (2.522 Å)