8HGK
Crystal structure of human ClpP in complex with ZK53
Summary for 8HGK
Entry DOI | 10.2210/pdb8hgk/pdb |
Descriptor | ATP-dependent Clp protease proteolytic subunit, mitochondrial, 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | activator, zk53, human clpp, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 14 |
Total formula weight | 345939.33 |
Authors | Yang, C.-G.,Gan, J.H.,Zhou, L.-L. (deposition date: 2022-11-14, release date: 2023-09-27, Last modification date: 2024-04-17) |
Primary citation | Zhou, L.L.,Zhang, T.,Xue, Y.,Yue, C.,Pan, Y.,Wang, P.,Yang, T.,Li, M.,Zhou, H.,Ding, K.,Gan, J.,Ji, H.,Yang, C.G. Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma. Nat Commun, 14:7069-7069, 2023 Cited by PubMed: 37923710DOI: 10.1038/s41467-023-42784-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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