8HGK

Crystal structure of human ClpP in complex with ZK53

Summary for 8HGK

• Entry DOI: 10.2210/pdb8hgk/pdb
• Descriptor: ATP-dependent Clp protease proteolytic subunit, mitochondrial, 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: activator, zk53, human clpp, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 14
• Total formula weight: 345939.33

Authors

Yang, C.-G.,Gan, J.H.,Zhou, L.-L. (deposition date: 2022-11-14, release date: 2023-09-27, Last modification date: 2024-04-17)

• Primary citation: Zhou, L.L.,Zhang, T.,Xue, Y.,Yue, C.,Pan, Y.,Wang, P.,Yang, T.,Li, M.,Zhou, H.,Ding, K.,Gan, J.,Ji, H.,Yang, C.G.; Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma.; Nat Commun, 14:7069-7069, 2023; PubMed: 37923710; DOI: 10.1038/s41467-023-42784-4

Experimental method

X-RAY DIFFRACTION (1.9 Å)