8HET

Crystal structure of CTSL in complex with E64d

Summary for 8HET

Entry DOI	10.2210/pdb8het/pdb
Descriptor	Procathepsin L, ethyl (3S)-3-hydroxy-4-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}amino)-4-oxobutanoate (3 entities in total)
Functional Keywords	inhibitor, antiviral, protease, antiviral protein, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	24536.15
Authors	Wang, H.,Shao, M.,Sun, L.,Yang, H. (deposition date: 2022-11-08, release date: 2023-12-13, Last modification date: 2024-06-19)
Primary citation	Wang, H.,Yang, Q.,Liu, X.,Xu, Z.,Shao, M.,Li, D.,Duan, Y.,Tang, J.,Yu, X.,Zhang, Y.,Hao, A.,Wang, Y.,Chen, J.,Zhu, C.,Guddat, L.,Chen, H.,Zhang, L.,Chen, X.,Jiang, B.,Sun, L.,Rao, Z.,Yang, H. Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun, 14:7574-7574, 2023 Cited by PubMed: 37990007 DOI: 10.1038/s41467-023-42527-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation