8HE8
Human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
Summary for 8HE8
Entry DOI | 10.2210/pdb8he8/pdb |
Descriptor | Poly [ADP-ribose] polymerase 2, GLYCEROL, 1-[[4-fluoranyl-3-(3-oxidanylidene-4-pentan-3-yl-piperazin-1-yl)carbonyl-phenyl]methyl]quinazoline-2,4-dione, ... (4 entities in total) |
Functional Keywords | parp-2, dna adp-ribosyltransferase, inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 121018.93 |
Authors | |
Primary citation | Zhou, J.,Du, T.,Wang, X.,Yao, H.,Deng, J.,Li, Y.,Chen, X.,Sheng, L.,Ji, M.,Xu, B. Discovery of Quinazoline-2,4(1 H ,3 H )-dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis. J.Med.Chem., 66:14095-14115, 2023 Cited by PubMed: 37843892DOI: 10.1021/acs.jmedchem.3c01152 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.05 Å) |
Structure validation
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