8HAY

d4-bound btDPP4

8HAY の概要

• エントリーDOI: 10.2210/pdb8hay/pdb
• 分子名称: btDPP4, (1~{R})-1-[[4-[5-[[(1~{R})-6,7-dimethoxy-2-methyl-3,4-dihydro-1~{H}-isoquinolin-1-yl]methyl]-2-methoxy-phenoxy]phenyl]methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1~{H}-isoquinoline (3 entities in total)
• 機能のキーワード: peptidase, gut microbiota, isozyme, secreted, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Bacteroides thetaiotaomicron
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 329405.13

構造登録者

Hang, J.,Jiang, C.,Wang, K.,Zhang, Z.,Guo, F.,Liu, J.,Wang, G.,Lei, X.,Gonzalez, F.,Qiao, J. (登録日: 2022-10-27, 公開日: 2023-07-26, 最終更新日: 2023-08-30)

• 主引用文献: Wang, K.,Zhang, Z.,Hang, J.,Liu, J.,Guo, F.,Ding, Y.,Li, M.,Nie, Q.,Lin, J.,Zhuo, Y.,Sun, L.,Luo, X.,Zhong, Q.,Ye, C.,Yun, C.,Zhang, Y.,Wang, J.,Bao, R.,Pang, Y.,Wang, G.,Gonzalez, F.J.,Lei, X.,Qiao, J.,Jiang, C.; Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target.; Science, 381:eadd5787-eadd5787, 2023; PubMed: 37535747; DOI: 10.1126/science.add5787

実験手法

X-RAY DIFFRACTION (2.74 Å)