8H7H

The crystal structure of human abl1 kinase domain in complex with abl1-A-EBA

Summary for 8H7H

• Entry DOI: 10.2210/pdb8h7h/pdb
• Descriptor: Tyrosine-protein kinase ABL1, 5-[3-(6-methoxyisoquinolin-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-methyl-N-prop-2-ynyl-pyridine-3-carboxamide (3 entities in total)
• Functional Keywords: complex, inhibitor, lysine, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 65020.16

Authors

Zhu, C.J.,Zhang, Z.M. (deposition date: 2022-10-20, release date: 2023-03-22, Last modification date: 2024-02-07)

• Primary citation: Chen, P.,Tang, G.,Zhu, C.,Sun, J.,Wang, X.,Xiang, M.,Huang, H.,Wang, W.,Li, L.,Zhang, Z.M.,Gao, L.,Yao, S.Q.; 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases.; J.Am.Chem.Soc., 2023; PubMed: 36774655; DOI: 10.1021/jacs.2c11595

Experimental method

X-RAY DIFFRACTION (2.27789711576 Å)