8H59

A fungal MAP kinase in complex with an inhibitor

Summary for 8H59

• Entry DOI: 10.2210/pdb8h59/pdb
• Descriptor: Mitogen-activated protein kinase MPS1, ~{N}-[(2~{S})-3-(1~{H}-indol-3-yl)-1-(methylamino)-1-oxidanylidene-propan-2-yl]-8-[2-methoxy-5-(trifluoromethyloxy)phenyl]-1,6-naphthyridine-2-carboxamide (3 entities in total)
• Functional Keywords: kinase, fungal, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Pyricularia oryzae 70-15
• Total number of polymer chains: 1
• Total formula weight: 46721.88

Authors

Kong, Z.,Zhang, X.,Wang, D.,Liu, J. (deposition date: 2022-10-12, release date: 2023-02-08, Last modification date: 2023-11-29)

• Primary citation: Kong, Z.,Zhang, X.,Zhou, F.,Tang, L.,Chen, Y.,Li, S.,Zhang, X.,Kuai, L.,Su, W.,Cui, W.,Cai, J.,Wang, Y.,Yang, J.,Peng, Y.L.,Wang, D.,Liu, J.; Structure-Aided Identification of an Inhibitor Targets Mps1 for the Management of Plant-Pathogenic Fungi.; Mbio, 14:e0288322-e0288322, 2023; PubMed: 36779710; DOI: 10.1128/mbio.02883-22

Experimental method

X-RAY DIFFRACTION (2.15 Å)