8H59

A fungal MAP kinase in complex with an inhibitor

8H59 の概要

• エントリーDOI: 10.2210/pdb8h59/pdb
• 分子名称: Mitogen-activated protein kinase MPS1, ~{N}-[(2~{S})-3-(1~{H}-indol-3-yl)-1-(methylamino)-1-oxidanylidene-propan-2-yl]-8-[2-methoxy-5-(trifluoromethyloxy)phenyl]-1,6-naphthyridine-2-carboxamide (3 entities in total)
• 機能のキーワード: kinase, fungal, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Pyricularia oryzae 70-15
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46721.88

構造登録者

Kong, Z.,Zhang, X.,Wang, D.,Liu, J. (登録日: 2022-10-12, 公開日: 2023-02-08, 最終更新日: 2023-11-29)

• 主引用文献: Kong, Z.,Zhang, X.,Zhou, F.,Tang, L.,Chen, Y.,Li, S.,Zhang, X.,Kuai, L.,Su, W.,Cui, W.,Cai, J.,Wang, Y.,Yang, J.,Peng, Y.L.,Wang, D.,Liu, J.; Structure-Aided Identification of an Inhibitor Targets Mps1 for the Management of Plant-Pathogenic Fungi.; Mbio, 14:e0288322-e0288322, 2023; PubMed: 36779710; DOI: 10.1128/mbio.02883-22

実験手法

X-RAY DIFFRACTION (2.15 Å)