8H3C

Crystal structure of M2e Influenza peptide in complex with antibody scFv

Summary for 8H3C

• Entry DOI: 10.2210/pdb8h3c/pdb
• Descriptor: Single Chain Variable Fragment, Matrix protein 2 (2 entities in total)
• Functional Keywords: single chain variable fragment, antiviral protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 7
• Total formula weight: 139135.67

Authors

Kumar, U.,Madni, Z.K.,Gaur, V.,Salunke, D.M. (deposition date: 2022-10-08, release date: 2023-08-02, Last modification date: 2024-11-13)

Primary citation

Kumar, U.,Goyal, P.,Madni, Z.K.,Kamble, K.,Gaur, V.,Rajala, M.S.,Salunke, D.M.
A structure and knowledge-based combinatorial approach to engineering universal scFv antibodies against influenza M2 protein.
J.Biomed.Sci., 30:56-56, 2023

PubMed Abstract: The influenza virus enters the host via hemagglutinin protein binding to cell surface sialic acid. Receptor-mediated endocytosis is followed by viral nucleocapsid uncoating for replication aided by the transmembrane viral M2 proton ion channel. M2 ectodomain (M2e) is a potential universal candidate for monoclonal antibody therapy owing to its conserved nature across influenza virus subtypes and its importance in viral propagation.

PubMed: 37491224
DOI: 10.1186/s12929-023-00950-2

Experimental method

X-RAY DIFFRACTION (3.43 Å)