8H3C

Crystal structure of M2e Influenza peptide in complex with antibody scFv

8H3C の概要

• エントリーDOI: 10.2210/pdb8h3c/pdb
• 分子名称: Single Chain Variable Fragment, Matrix protein 2 (2 entities in total)
• 機能のキーワード: single chain variable fragment, antiviral protein
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 7
• 化学式量合計: 139135.67

構造登録者

Kumar, U.,Madni, Z.K.,Gaur, V.,Salunke, D.M. (登録日: 2022-10-08, 公開日: 2023-08-02, 最終更新日: 2024-11-13)

主引用文献

Kumar, U.,Goyal, P.,Madni, Z.K.,Kamble, K.,Gaur, V.,Rajala, M.S.,Salunke, D.M.
A structure and knowledge-based combinatorial approach to engineering universal scFv antibodies against influenza M2 protein.
J.Biomed.Sci., 30:56-56, 2023

PubMed Abstract: The influenza virus enters the host via hemagglutinin protein binding to cell surface sialic acid. Receptor-mediated endocytosis is followed by viral nucleocapsid uncoating for replication aided by the transmembrane viral M2 proton ion channel. M2 ectodomain (M2e) is a potential universal candidate for monoclonal antibody therapy owing to its conserved nature across influenza virus subtypes and its importance in viral propagation.

PubMed: 37491224
DOI: 10.1186/s12929-023-00950-2

実験手法

X-RAY DIFFRACTION (3.43 Å)