8GXP
Complex structure of RORgama with betulinic acid
Summary for 8GXP
| Entry DOI | 10.2210/pdb8gxp/pdb |
| Descriptor | Nuclear receptor ROR-gamma, Betulinic acid (3 entities in total) |
| Functional Keywords | rorgama, antagonist, complex, nuclear protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 31694.79 |
| Authors | Zhang, X.L.,Xu, C.,Bai, F. (deposition date: 2022-09-20, release date: 2023-06-07, Last modification date: 2023-11-08) |
| Primary citation | Mei, L.,Xu, L.,Wu, S.,Wang, Y.,Xu, C.,Wang, L.,Zhang, X.,Yu, C.,Jiang, H.,Zhang, X.,Bai, F.,Xie, C. Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of ROR gamma antagonists. Eur.J.Med.Chem., 257:115472-115472, 2023 Cited by PubMed: 37236000DOI: 10.1016/j.ejmech.2023.115472 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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