8GWR

Near full length Kidney type Glutaminase in complex with 2,2-Dimethyl-2,3-Dihydrobenzo[a] Phenanthridin-4(1H)-one (DDP)

8GWR の概要

• エントリーDOI: 10.2210/pdb8gwr/pdb
• 分子名称: Glutaminase kidney isoform, mitochondrial, 2,2-dimethyl-1,3-dihydrobenzo[a]phenanthridin-4-one (3 entities in total)
• 機能のキーワード: glutaminase, complex, allosteric inhibition, small molecule inhibitor, cancer, oncoprotein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 147383.33

構造登録者

Shankar, S.,Jobichen, C.,Sivaraman, J. (登録日: 2022-09-17, 公開日: 2022-12-21, 最終更新日: 2023-11-29)

• 主引用文献: Shankar, S.,Ramachandran, S.,Tulsian, N.,Radhakrishnan, S.,Jobichen, C.,Sivaraman, J.; A novel allosteric site employs a conserved inhibition mechanism in human kidney-type glutaminase.; Febs J., 290:2437-2448, 2023; PubMed: 36259273; DOI: 10.1111/febs.16658

実験手法

X-RAY DIFFRACTION (2.801 Å)