8GT1

Crystal structure of human cardiac alpha actin A108G mutant (ADP-Pi state) in complex with fragmin F1 domain

Summary for 8GT1

• Entry DOI: 10.2210/pdb8gt1/pdb
• Descriptor: Actin, alpha cardiac muscle 1, Actin-binding protein fragmin P, ADENOSINE-5'-DIPHOSPHATE, ... (9 entities in total)
• Functional Keywords: actin dynamics, atp hydrolysis, mutagenesis, md simulation, contractile protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 63393.93

Authors

Iwasa, M.,Oda, T.,Takeda, S. (deposition date: 2022-09-07, release date: 2023-03-08, Last modification date: 2023-11-29)

• Primary citation: Iwasa, M.,Takeda, S.,Narita, A.,Maeda, Y.,Oda, T.; Mutagenic analysis of actin reveals the mechanism of His161 flipping that triggers ATP hydrolysis.; Front Cell Dev Biol, 11:1105460-1105460, 2023; PubMed: 37009486; DOI: 10.3389/fcell.2023.1105460

Experimental method

X-RAY DIFFRACTION (1.35 Å)