8GSQ

Structure based studies reveal an atypical antipsychotic drug candidate - Paliperidone as a potent hSOD1 modulator with implications in ALS treatment.

8GSQ の概要

• エントリーDOI: 10.2210/pdb8gsq/pdb
• 分子名称: Superoxide dismutase [Cu-Zn], ZINC ION, GLYCEROL, ... (8 entities in total)
• 機能のキーワード: superoxide dismutase, als, antipsychotic, oxidation, oxidoreductase-inhibitor complex, oxidoreductase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 160801.82

構造登録者

Aouti, S.,Padmanabhan, B. (登録日: 2022-09-06, 公開日: 2023-06-14, 最終更新日: 2023-09-20)

• 主引用文献: Aouti, S.,Padavattan, S.,Padmanabhan, B.; Structure-based discovery of an antipsychotic drug, paliperidone, as a modulator of human superoxide dismutase 1: a potential therapeutic target in amyotrophic lateral sclerosis.; Acta Crystallogr D Struct Biol, 79:531-544, 2023; PubMed: 37204819; DOI: 10.1107/S2059798323003649

実験手法

X-RAY DIFFRACTION (2.1 Å)