8GS6

Structure of the SARS-CoV-2 BA.2.75 spike glycoprotein (closed state 1)

8GS6 の概要

• エントリーDOI: 10.2210/pdb8gs6/pdb
• EMDBエントリー: 34221
• 分子名称: Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: spike glycoprotein, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 423976.81

構造登録者

Anraku, Y.,Tabata-Sasaki, K.,Kita, S.,Fukuhara, H.,Maenaka, K.,Hashiguchi, T. (登録日: 2022-09-05, 公開日: 2022-10-26, 最終更新日: 2024-10-16)

主引用文献

Saito, A.,Tamura, T.,Zahradnik, J.,Deguchi, S.,Tabata, K.,Anraku, Y.,Kimura, I.,Ito, J.,Yamasoba, D.,Nasser, H.,Toyoda, M.,Nagata, K.,Uriu, K.,Kosugi, Y.,Fujita, S.,Shofa, M.,Monira Begum, M.,Shimizu, R.,Oda, Y.,Suzuki, R.,Ito, H.,Nao, N.,Wang, L.,Tsuda, M.,Yoshimatsu, K.,Kuramochi, J.,Kita, S.,Sasaki-Tabata, K.,Fukuhara, H.,Maenaka, K.,Yamamoto, Y.,Nagamoto, T.,Asakura, H.,Nagashima, M.,Sadamasu, K.,Yoshimura, K.,Ueno, T.,Schreiber, G.,Takaori-Kondo, A.,Shirakawa, K.,Sawa, H.,Irie, T.,Hashiguchi, T.,Takayama, K.,Matsuno, K.,Tanaka, S.,Ikeda, T.,Fukuhara, T.,Sato, K.
Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant.
Cell Host Microbe, 30:1540-1555.e15, 2022

PubMed Abstract: The SARS-CoV-2 Omicron BA.2.75 variant emerged in May 2022. BA.2.75 is a BA.2 descendant but is phylogenetically distinct from BA.5, the currently predominant BA.2 descendant. Here, we show that BA.2.75 has a greater effective reproduction number and different immunogenicity profile than BA.5. We determined the sensitivity of BA.2.75 to vaccinee and convalescent sera as well as a panel of clinically available antiviral drugs and antibodies. Antiviral drugs largely retained potency, but antibody sensitivity varied depending on several key BA.2.75-specific substitutions. The BA.2.75 spike exhibited a profoundly higher affinity for its human receptor, ACE2. Additionally, the fusogenicity, growth efficiency in human alveolar epithelial cells, and intrinsic pathogenicity in hamsters of BA.2.75 were greater than those of BA.2. Our multilevel investigations suggest that BA.2.75 acquired virological properties independent of BA.5, and the potential risk of BA.2.75 to global health is greater than that of BA.5.

PubMed: 36272413
DOI: 10.1016/j.chom.2022.10.003

実験手法

ELECTRON MICROSCOPY (2.86 Å)