8GS5
Crystal structure of a constitutively active mutant of human IDH3 holoenzyme in apo form
Summary for 8GS5
Entry DOI | 10.2210/pdb8gs5/pdb |
Descriptor | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, Isoform A of Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (3 entities in total) |
Functional Keywords | isocitrate dehydrogenase, nad-dependent idh, assembly, allosteric regulation, oxidoreductase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 16 |
Total formula weight | 605079.22 |
Authors | |
Primary citation | Chen, X.,Sun, P.,Liu, Y.,Shen, S.,Ma, T.,Ding, J. Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction. J.Biol.Chem., 298:102695-102695, 2022 Cited by PubMed: 36375638DOI: 10.1016/j.jbc.2022.102695 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.486 Å) |
Structure validation
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