8GRU

Crystal structure of a constitutively active mutant of the alpha beta heterodimer of human IDH3 in complex with ICT, NAD and Ca

8GRU の概要

• エントリーDOI: 10.2210/pdb8gru/pdb
• 分子名称: Human IDH3 alpha subunit, Isoform A of Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (5 entities in total)
• 機能のキーワード: isocitrate dehydrogenase, nad-dependent idh, assembly, allosteric regulation, oxidoreductase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 154672.42

構造登録者

Sun, P.,Chen, X.,Ding, J. (登録日: 2022-09-02, 公開日: 2022-11-30, 最終更新日: 2023-11-29)

• 主引用文献: Chen, X.,Sun, P.,Liu, Y.,Shen, S.,Ma, T.,Ding, J.; Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction.; J.Biol.Chem., 298:102695-102695, 2022; PubMed: 36375638; DOI: 10.1016/j.jbc.2022.102695

実験手法

X-RAY DIFFRACTION (2.847 Å)