8GRG

Crystal structure of a constitutively active mutant of the alpha gamma heterodimer of human IDH3

8GRG の概要

• エントリーDOI: 10.2210/pdb8grg/pdb
• 分子名称: Human IDH3 alpha subunit, Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (3 entities in total)
• 機能のキーワード: isocitrate dehydrogenase, idh3, nad-dependent idh, assembly, allosteric regulation, oxidoreductase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75492.65

構造登録者

Sun, P.,Chen, X.,Ding, J. (登録日: 2022-09-01, 公開日: 2022-11-30, 最終更新日: 2023-11-29)

• 主引用文献: Chen, X.,Sun, P.,Liu, Y.,Shen, S.,Ma, T.,Ding, J.; Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction.; J.Biol.Chem., 298:102695-102695, 2022; PubMed: 36375638; DOI: 10.1016/j.jbc.2022.102695

実験手法

X-RAY DIFFRACTION (2.699 Å)