8GPZ

Crystal structure of BRD4 bromodomain 1 (BD1) in complex with C239-0012

Summary for 8GPZ

Entry DOI	10.2210/pdb8gpz/pdb
Descriptor	Bromodomain-containing protein 4, FORMIC ACID, SODIUM ION, ... (5 entities in total)
Functional Keywords	bd1, complex, inhibitor, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	15100.41
Authors	Park, T.H.,Lee, B.I. (deposition date: 2022-08-27, release date: 2023-01-18, Last modification date: 2023-11-29)
Primary citation	Kim, J.H.,Pandit, N.,Yoo, M.,Park, T.H.,Choi, J.U.,Park, C.H.,Jung, K.Y.,Lee, B.I. Crystal structure of [1,2,4]triazolo[4,3-b]pyridazine derivatives as BRD4 bromodomain inhibitors and structure-activity relationship study. Sci Rep, 13:10805-10805, 2023 Cited by PubMed: 37402749 DOI: 10.1038/s41598-023-37527-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.528 Å)

Structure validation