8GPD
Crystal structure of NDM-1 at pH5.5 (Succinate) in complex with hydrolyzed penicillin V
Summary for 8GPD
Entry DOI | 10.2210/pdb8gpd/pdb |
Descriptor | Metallo beta lactamase NDM-1, ZINC ION, (2R,4S)-5,5-dimethyl-2-[(1R)-2-oxidanyl-2-oxidanylidene-1-(2-phenoxyethanoylamino)ethyl]-1,3-thiazolidine-4-carboxylic acid, ... (5 entities in total) |
Functional Keywords | hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 2 |
Total formula weight | 58092.40 |
Authors | |
Primary citation | Shi, X.,Dai, Y.,Lan, Z.,Wang, S.,Cui, L.,Xiao, C.,Zhao, K.,Li, X.,Liu, W.,Zhang, Q. Interplay between the beta-lactam side chain and an active-site mobile loop of NDM-1 in penicillin hydrolysis as a potential target for mechanism-based inhibitor design. Int.J.Biol.Macromol., 262:130041-130041, 2024 Cited by PubMed: 38336327DOI: 10.1016/j.ijbiomac.2024.130041 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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