8GPD

Crystal structure of NDM-1 at pH5.5 (Succinate) in complex with hydrolyzed penicillin V

8GPD の概要

• エントリーDOI: 10.2210/pdb8gpd/pdb
• 分子名称: Metallo beta lactamase NDM-1, ZINC ION, (2R,4S)-5,5-dimethyl-2-[(1R)-2-oxidanyl-2-oxidanylidene-1-(2-phenoxyethanoylamino)ethyl]-1,3-thiazolidine-4-carboxylic acid, ... (5 entities in total)
• 機能のキーワード: hydrolase
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58092.40

構造登録者

Shi, X.,Dai, Y.,Zhang, Q.,Liu, W. (登録日: 2022-08-26, 公開日: 2023-08-30, 最終更新日: 2024-02-28)

• 主引用文献: Shi, X.,Dai, Y.,Lan, Z.,Wang, S.,Cui, L.,Xiao, C.,Zhao, K.,Li, X.,Liu, W.,Zhang, Q.; Interplay between the beta-lactam side chain and an active-site mobile loop of NDM-1 in penicillin hydrolysis as a potential target for mechanism-based inhibitor design.; Int.J.Biol.Macromol., 262:130041-130041, 2024; PubMed: 38336327; DOI: 10.1016/j.ijbiomac.2024.130041

実験手法

X-RAY DIFFRACTION (1.4 Å)