8GOT

Crystal structure of wild-type protease 3C from Seneca Valley Virus

Summary for 8GOT

Entry DOI	10.2210/pdb8got/pdb
Descriptor	Peptidase C3, [(2~{S})-2-hexadecanoyloxy-3-[[(2~{R})-3-[[(2~{S})-3-[(5~{E},8~{E},11~{Z},14~{E})-icosa-5,8,11,14-tetraenoyl]oxy-2-[(9~{E},12~{Z})-octadeca-9,12-dienoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-2-oxidanyl-propoxy]-oxidanyl-phosphoryl]oxy-propyl] icosanoate, GLYCEROL, ... (4 entities in total)
Functional Keywords	seneca valley virus, 3c protease, phospholipid, viral protein
Biological source	Senecavirus A
Total number of polymer chains	1
Total formula weight	24567.37
Authors	Zhao, H.F.,Zhang, H. (deposition date: 2022-08-25, release date: 2023-05-24, Last modification date: 2024-06-05)
Primary citation	Zhao, H.F.,Meng, L.,Geng, Z.,Gao, Z.Q.,Dong, Y.H.,Wang, H.W.,Zhang, H. Allosteric regulation of Senecavirus A 3Cpro proteolytic activity by an endogenous phospholipid. Plos Pathog., 19:e1011411-e1011411, 2023 Cited by PubMed: 37253057 DOI: 10.1371/journal.ppat.1011411 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.989 Å)

Structure validation