8GM5
Functional construct of the Eukaryotic elongation factor 2 kinase bound to Calmodulin, ADP and to the A-484954 inhibitor and showing two conformations for the 498-520 loop
Summary for 8GM5
Entry DOI | 10.2210/pdb8gm5/pdb |
Descriptor | Eukaryotic elongation factor 2 kinase, Calmodulin-1, ADENOSINE-5'-DIPHOSPHATE, ... (7 entities in total) |
Functional Keywords | elongation factor 2 kinase, eef2, eef2k, eef-2k, calmodulin, translation, a-484954, adp, allostery, translation-transferase complex, alternate conformations, signaling protein, translation/transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 77964.13 |
Authors | Piserchio, A.,Isiorho, E.A.,Dalby, K.N.,Ghose, R. (deposition date: 2023-03-24, release date: 2023-05-31, Last modification date: 2023-10-25) |
Primary citation | Piserchio, A.,Isiorho, E.A.,Dalby, K.N.,Ghose, R. Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor. J.Biol.Chem., 299:104813-104813, 2023 Cited by PubMed: 37172726DOI: 10.1016/j.jbc.2023.104813 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.12 Å) |
Structure validation
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