8GM5

Functional construct of the Eukaryotic elongation factor 2 kinase bound to Calmodulin, ADP and to the A-484954 inhibitor and showing two conformations for the 498-520 loop

8GM5 の概要

• エントリーDOI: 10.2210/pdb8gm5/pdb
• 分子名称: Eukaryotic elongation factor 2 kinase, Calmodulin-1, ADENOSINE-5'-DIPHOSPHATE, ... (7 entities in total)
• 機能のキーワード: elongation factor 2 kinase, eef2, eef2k, eef-2k, calmodulin, translation, a-484954, adp, allostery, translation-transferase complex, alternate conformations, signaling protein, translation/transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77964.13

構造登録者

Piserchio, A.,Isiorho, E.A.,Dalby, K.N.,Ghose, R. (登録日: 2023-03-24, 公開日: 2023-05-31, 最終更新日: 2023-10-25)

• 主引用文献: Piserchio, A.,Isiorho, E.A.,Dalby, K.N.,Ghose, R.; Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor.; J.Biol.Chem., 299:104813-104813, 2023; PubMed: 37172726; DOI: 10.1016/j.jbc.2023.104813

実験手法

X-RAY DIFFRACTION (2.12 Å)