8GK5
EGFR(T790M/V948R) kinase in complex with osimertinib and benzimidazole allosteric inhibitor
Summary for 8GK5
Entry DOI | 10.2210/pdb8gk5/pdb |
Descriptor | Epidermal growth factor receptor, ~{N}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide, 2-[(R)-(1H-benzimidazol-2-yl)(3-fluorophenyl)methyl]-6-[4-(1-methylpiperidin-4-yl)phenyl]-2,3-dihydro-1H-isoindol-1-one, ... (4 entities in total) |
Functional Keywords | egfr, kinase, covalent, inhibitor, allosteric, cancer, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 155027.42 |
Authors | |
Primary citation | Beyett, T.S.,Eck, M.J. Development of benzimidazole allosteric EGFR kinase inhibitors To be published, |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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