8GK5
EGFR(T790M/V948R) kinase in complex with osimertinib and benzimidazole allosteric inhibitor
8GK5 の概要
エントリーDOI | 10.2210/pdb8gk5/pdb |
分子名称 | Epidermal growth factor receptor, ~{N}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide, 2-[(R)-(1H-benzimidazol-2-yl)(3-fluorophenyl)methyl]-6-[4-(1-methylpiperidin-4-yl)phenyl]-2,3-dihydro-1H-isoindol-1-one, ... (4 entities in total) |
機能のキーワード | egfr, kinase, covalent, inhibitor, allosteric, cancer, transferase, transferase-inhibitor complex, transferase/inhibitor |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 155027.42 |
構造登録者 | |
主引用文献 | Beyett, T.S.,Eck, M.J. Development of benzimidazole allosteric EGFR kinase inhibitors To be published, |
実験手法 | X-RAY DIFFRACTION (2.3 Å) |
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