8GK5

EGFR(T790M/V948R) kinase in complex with osimertinib and benzimidazole allosteric inhibitor

8GK5 の概要

• エントリーDOI: 10.2210/pdb8gk5/pdb
• 分子名称: Epidermal growth factor receptor, ~{N}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide, 2-[(R)-(1H-benzimidazol-2-yl)(3-fluorophenyl)methyl]-6-[4-(1-methylpiperidin-4-yl)phenyl]-2,3-dihydro-1H-isoindol-1-one, ... (4 entities in total)
• 機能のキーワード: egfr, kinase, covalent, inhibitor, allosteric, cancer, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 155027.42

構造登録者

Beyett, T.S.,Eck, M.J. (登録日: 2023-03-17, 公開日: 2024-06-26, 最終更新日: 2024-11-20)

• 主引用文献: Beyett, T.S.,Eck, M.J.; Development of benzimidazole allosteric EGFR kinase inhibitors; To be published,

実験手法

X-RAY DIFFRACTION (2.3 Å)