8GJT

Crystal Structure of HIV-1 LM/HT Clade A/E CRF01 GP120 Core in Complex with TFH-I-116-D1

8GJT の概要

• エントリーDOI: 10.2210/pdb8gjt/pdb
• 分子名称: HIV-1 LM/HT Clade A/E CRF01 gp120 core, 2-acetamido-2-deoxy-beta-D-glucopyranose, (3S)-N-(4-chloro-3-fluorophenyl)-1-[(3R,5S)-3,4,5-trimethylpiperazine-1-carbonyl]piperidine-3-carboxamide, ... (5 entities in total)
• 機能のキーワード: hiv-1 gp120, clade a/e cf01, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42363.50

構造登録者

Tolbert, W.D.,Nguyen, D.N.,Pazgier, M. (登録日: 2023-03-16, 公開日: 2023-06-07)

• 主引用文献: Ding, S.,Tolbert, W.D.,Zhu, H.,Lee, D.,Marchitto, L.,Higgins, T.,Zhao, X.,Nguyen, D.,Sherburn, R.,Richard, J.,Gendron-Lepage, G.,Medjahed, H.,Mohammadi, M.,Abrams, C.,Pazgier, M.,Smith III, A.B.,Finzi, A.; Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC.; Viruses, 15:-, 2023; PubMed: 37243271; DOI: 10.3390/v15051185

実験手法

X-RAY DIFFRACTION (3.5 Å)