8GIH

Structure of Hepatitis B Virus Capsid Y132A mutant in complex with Compound 24

Summary for 8GIH

• Entry DOI: 10.2210/pdb8gih/pdb
• Descriptor: Capsid protein, CHLORIDE ION, (6S,8R)-N-(3-bromo-4-fluorophenyl)-8-fluoro-10-methyl-11-oxo-1,3,4,7,8,9,10,11-octahydro-2H-pyrido[4',3':3,4]pyrazolo[1,5-a][1,4]diazepine-2-carboxamide, ... (4 entities in total)
• Functional Keywords: hbv, capsid assembly, core protein, viral protein, inhibitor complex, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Hepatitis B virus (HBV)
• Total number of polymer chains: 6
• Total formula weight: 111178.52

Authors

Shaffer, P.L. (deposition date: 2023-03-14, release date: 2023-04-12, Last modification date: 2023-10-25)

• Primary citation: Kuduk, S.D.,DeRatt, L.G.,Stoops, B.,Shaffer, P.,Lam, A.M.,Espiritu, C.,Vogel, R.,Lau, V.,Flores, O.A.,Hartman, G.D.; Diazepinone HBV capsid assembly modulators.; Bioorg Med Chem Lett, 72:128823-, 2022; PubMed: 35644301; DOI: 10.1016/j.bmcl.2022.128823

Experimental method

X-RAY DIFFRACTION (2.65 Å)