8GH5

Implementing Logic Gates in DNA Crystal Engineering

Summary for 8GH5

• Entry DOI: 10.2210/pdb8gh5/pdb
• Descriptor: DNA (5'-D(*AP*GP*AP*CP*G)-3'), DNA (5'-D(P*CP*GP*TP*GP*GP*A)-3'), DNA (5'-D(P*TP*CP*CP*GP*A)-3'), ... (5 entities in total)
• Functional Keywords: two motifs per asymmetric unit, dna
• Biological source: synthetic construct; More
• Total number of polymer chains: 6
• Total formula weight: 9618.53

Authors

Zhang, C.,Paluzzi, V.E.,Sha, R.,Jonoska, N.,Mao, C. (deposition date: 2023-03-09, release date: 2023-06-07, Last modification date: 2023-10-25)

Primary citation

Zhang, C.,Paluzzi, V.E.,Sha, R.,Jonoska, N.,Mao, C.
Implementing Logic Gates by DNA Crystal Engineering.
Adv Mater, 35:e2302345-e2302345, 2023

PubMed Abstract: DNA self-assembly computation is attractive for its potential to perform massively parallel information processing at the molecular level while at the same time maintaining its natural biocompatibility. It has been extensively studied at the individual molecule level, but not as much as ensembles in 3D. Here, the feasibility of implementing logic gates, the basic computation operations, in large ensembles: macroscopic, engineered 3D DNA crystals is demonstrated. The building blocks are the recently developed DNA double crossover-like (DXL) motifs. They can associate with each other via sticky-end cohesion. Common logic gates are realized by encoding the inputs within the sticky ends of the motifs. The outputs are demonstrated through the formation of macroscopic crystals that can be easily observed. This study points to a new direction of construction of complex 3D crystal architectures and DNA-based biosensors with easy readouts.

PubMed: 37220213
DOI: 10.1002/adma.202302345

Experimental method

X-RAY DIFFRACTION (2.64 Å)