8GGI
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #1 of 20)
Summary for 8GGI
Entry DOI | 10.2210/pdb8ggi/pdb |
Related | 8GFV |
EMDB information | 29985 40009 |
Descriptor | Beta-2 adrenergic receptor, (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol (3 entities in total) |
Functional Keywords | gpcr, adrenergic, receptor, g protein, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 51976.48 |
Authors | Papasergi-Scott, M.M.,Skiniotis, G. (deposition date: 2023-03-08, release date: 2024-03-06, Last modification date: 2024-06-05) |
Primary citation | Papasergi-Scott, M.M.,Perez-Hernandez, G.,Batebi, H.,Gao, Y.,Eskici, G.,Seven, A.B.,Panova, O.,Hilger, D.,Casiraghi, M.,He, F.,Maul, L.,Gmeiner, P.,Kobilka, B.K.,Hildebrand, P.W.,Skiniotis, G. Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629:1182-1191, 2024 Cited by PubMed: 38480881DOI: 10.1038/s41586-024-07153-1 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
Download full validation report