8GDN

Structure of PmHMGR bound to mevalonate, CoA and NAD.

Summary for 8GDN

• Entry DOI: 10.2210/pdb8gdn/pdb
• Descriptor: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, COENZYME A, (R)-MEVALONATE, ... (6 entities in total)
• Functional Keywords: non-rossmann fold, homodimer, reductase, hmg-coa, structural protein
• Biological source: Pseudomonas sp. 'mevalonii'
• Total number of polymer chains: 2
• Total formula weight: 93199.87

Authors

Purohit, V.,Steussy, C.N.,Stauffacher, C.V. (deposition date: 2023-03-06, release date: 2024-03-20)

• Primary citation: Purohit, V.,Steussy, C.N.,Rosales, A.R.,Critchelow, C.J.,Schmidt, T.,Helquist, P.,Wiest, O.,Mesecar, A.,Cohen, A.E.,Stauffacher, C.V.; pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography.; Biophys.J., 123:622-637, 2024; PubMed: 38327055; DOI: 10.1016/j.bpj.2024.02.003

Experimental method

X-RAY DIFFRACTION (1.99 Å)