8GD4

Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with DMFO Inhibitor 6

8GD4 の概要

• エントリーDOI: 10.2210/pdb8gd4/pdb
• 分子名称: Hdac6 protein, 2-(benzylamino)-N'-(difluoroacetyl)pyrimidine-5-carbohydrazide, ZINC ION, ... (5 entities in total)
• 機能のキーワード: hydrolase, histone deacetylase, inhibitor, metallohydrolase
• 由来する生物種: Danio rerio (zebrafish)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81500.74

構造登録者

Watson, P.R.,Craigin, A.D.,Christianson, D.W. (登録日: 2023-03-03, 公開日: 2023-10-04, 最終更新日: 2023-10-25)

• 主引用文献: Konig, B.,Watson, P.R.,Ressing, N.,Cragin, A.D.,Schaker-Hubner, L.,Christianson, D.W.,Hansen, F.K.; Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6 .; J.Med.Chem., 66:13821-13837, 2023; PubMed: 37782298; DOI: 10.1021/acs.jmedchem.3c01345

実験手法

X-RAY DIFFRACTION (2 Å)