8GD2
Crystal structure of human cellular retinol binding protein 1 in complex with N-methyl-1-{3-[1-(4-methylphenyl)cyclopentyl]-1,2,4-oxadiazol-5-yl}-N-(2-thienylmethyl)methanamine
Summary for 8GD2
Entry DOI | 10.2210/pdb8gd2/pdb |
Descriptor | Retinol-binding protein 1, N-methyl-1-{3-[1-(4-methylphenyl)cyclopentyl]-1,2,4-oxadiazol-5-yl}-N-[(thiophen-2-yl)methyl]methanamine, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total) |
Functional Keywords | rbp1, crbp1, retinol-binding, retinol, vitamin a, retinol-binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 17276.81 |
Authors | Plau, J.,Golczak, M. (deposition date: 2023-03-03, release date: 2023-10-04, Last modification date: 2023-11-01) |
Primary citation | Plau, J.,Morgan, C.E.,Fedorov, Y.,Banerjee, S.,Adams, D.J.,Blaner, W.S.,Yu, E.W.,Golczak, M. Discovery of Nonretinoid Inhibitors of CRBP1: Structural and Dynamic Insights for Ligand-Binding Mechanisms. Acs Chem.Biol., 18:2309-2323, 2023 Cited by PubMed: 37713257DOI: 10.1021/acschembio.3c00402 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.13 Å) |
Structure validation
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