8GCC
T. cruzi topoisomerase II alpha bound to dsDNA and the covalent inhibitor CT1
Summary for 8GCC
Entry DOI | 10.2210/pdb8gcc/pdb |
EMDB information | 29930 |
Descriptor | DNA topoisomerase 2, DNA (28-MER), 2-{3-[(Z)-iminomethyl]-1H-1,2,4-triazol-1-yl}-1-{(3M)-3-[2-(trifluoromethyl)phenyl]-6H-pyrrolo[3,4-b]pyridin-6-yl}ethan-1-one (3 entities in total) |
Functional Keywords | topoisomerase, dna binding protein, topoisomerase inhibitor, isomerase |
Biological source | Trypanosoma cruzi strain CL Brener More |
Total number of polymer chains | 4 |
Total formula weight | 196650.69 |
Authors | |
Primary citation | Rao, S.P.S.,Gould, M.K.,Noeske, J.,Saldivia, M.,Jumani, R.S.,Ng, P.S.,Rene, O.,Chen, Y.L.,Kaiser, M.,Ritchie, R.,Francisco, A.F.,Johnson, N.,Patra, D.,Cheung, H.,Deniston, C.,Schenk, A.D.,Cortopassi, W.A.,Schmidt, R.S.,Wiedemar, N.,Thomas, B.,Palkar, R.,Ghafar, N.A.,Manoharan, V.,Luu, C.,Gable, J.E.,Wan, K.F.,Myburgh, E.,Mottram, J.C.,Barnes, W.,Walker, J.,Wartchow, C.,Aziz, N.,Osborne, C.,Wagner, J.,Sarko, C.,Kelly, J.M.,Manjunatha, U.H.,Maeser, P.,Jiricek, J.,Lakshminarayana, S.B.,Barrett, M.P.,Diagana, T.T. Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science, 380:1349-1356, 2023 Cited by PubMed: 37384702DOI: 10.1126/science.adh0614 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.94 Å) |
Structure validation
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