8GC1
Crystal structure of the unmutated common ancestor (UCA) of the PC39-1 anti-HIV broadly neutralizing antibody lineage
Summary for 8GC1
Entry DOI | 10.2210/pdb8gc1/pdb |
Related | 8GBV 8GBW 8GBX 8GBY 8GBZ 8GC0 |
Descriptor | PC39-1 UCA Fab heavy chain, PC39-1 UCA Fab light chain (2 entities in total) |
Functional Keywords | antibody, broadly neutralizing, hiv-1, v3 glycan, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 48220.64 |
Authors | Murrell, S.,Omorodion, O.,Wilson, I.A. (deposition date: 2023-02-28, release date: 2023-06-07, Last modification date: 2023-07-12) |
Primary citation | Joyce, C.,Murrell, S.,Murrell, B.,Omorodion, O.,Ver, L.S.,Carrico, N.,Bastidas, R.,Nedellec, R.,Bick, M.,Woehl, J.,Zhao, F.,Burns, A.,Barman, S.,Appel, M.,Ramos, A.,Wickramasinghe, L.,Eren, K.,Vollbrecht, T.,Smith, D.M.,Kosakovsky Pond, S.L.,McBride, R.,Worth, C.,Batista, F.,Sok, D.,Poignard, P.,Briney, B.,Wilson, I.A.,Landais, E.,Burton, D.R. Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies. Plos Pathog., 19:e1011416-e1011416, 2023 Cited by PubMed: 37384622DOI: 10.1371/journal.ppat.1011416 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.19 Å) |
Structure validation
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