8GB1

Crystal structure of SAMHD1 dimer bound to deoxyguanosine linked inhibitor

8GB1 の概要

• エントリーDOI: 10.2210/pdb8gb1/pdb
• 分子名称: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 5'-O-[(R)-(3-{[(1M)-3'-bromo[1,1'-biphenyl]-3-carbonyl]amino}propoxy)(hydroxy)phosphoryl]-2'-deoxyguanosine, FE (III) ION, ... (4 entities in total)
• 機能のキーワード: samhd1, dntpase, hydrolase, inhibitor, deoxyguanosine linked inhibitor, hydrolase inhibitor, dimer, dimeric
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 242094.57

構造登録者

Egleston, M.,Dong, L.,Howlader, A.H.,Bhat, S.,Orris, B.,Bianchet, M.A.,Greenberg, M.M.,Stivers, J.T. (登録日: 2023-02-24, 公開日: 2023-06-07, 最終更新日: 2023-11-01)

• 主引用文献: Egleston, M.,Dong, L.,Howlader, A.H.,Bhat, S.,Orris, B.,Bianchet, M.A.,Greenberg, M.M.,Stivers, J.T.; Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding.; Acs Chem.Biol., 18:2200-2210, 2023; PubMed: 37233733; DOI: 10.1021/acschembio.3c00118

実験手法

X-RAY DIFFRACTION (2.46 Å)